Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.

doi:10.1093/schbul/sbag021

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.

Schizophrenia bulletin - 7 Mar 2026

Ni Chaoying, Liu Jin-Ming, Yang Tengfei, Deng Zhiying, Wu Xiaohui, Li Shufen, Xue Hannah, Wang Zhongju, Cao Xiong, Zhao Cunyou

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Allele-specific expression (ASE) of long non-coding RNAs (lncRNAs) links genetic variation to synaptic dysfunction in psychiatric disorders. We previously identified a disease-associated ASE shift in LINC02449 at rs149707223 (C/G), with preferential expression of the alternative G allele in bipolar disorder (BD) and schizophrenia (SZ). Overexpression of LINC02449-G induced social...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Amino Acid Antagonists

Share to Mice, Inbred C57BL

Share to Neuroprotective Agents

Share to Nucleus Accumbens

Share to Prefrontal Cortex

Share to RNA, Long Noncoding

Share to Schizophrenia

Source

Open in PubMed Open full text

Identifiers

PMID: 41863379
DOI: 10.1093/schbul/sbag021
PMCID: PMC13005127

Genes

CPLX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Riluzole Restores Circuit and Behavioral Function Altered by Allele-Specific Expression-Mediated LINC02449-CPLX1 Dysregulation.PMID 41863379Read ↗

Mutation of novel ethanol-responsive lncRNA Gm41261 impacts ethanol-related behavioral responses in mice.Semantic proximity Read ↗

Setd1a Insufficiency in Mice Attenuates Excitatory Synaptic Function and Recapitulates Schizophrenia-Related Behavioral Abnormalities.Semantic proximity Read ↗

Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compoundsSemantic proximity Read ↗

Bridging the scales: leveraging personalized disease models and deep phenotyping to dissect cognitive impairment in schizophreniaSemantic proximity Read ↗

Lateral Septal Circuits Govern Schizophrenia-Like Effects of Ketamine on Social BehaviorSemantic proximity Read ↗

Schizophrenia-associated 22q11.2 deletion elevates striatal acetylcholine and disrupts thalamostriatal projections to produce amotivation in miceSemantic proximity Read ↗

Aberrant encoding of event saliency in the orbitofrontal cortex following loss of the psychiatric-associated circular RNA, circHomer1Semantic proximity Read ↗

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.Semantic proximity Read ↗

Change in brain molecular landscapes following electrical stimulation of the nucleus accumbensSemantic proximity Read ↗

The basolateral amygdala-anterior cingulate pathway contributes to depression and its comorbidity with chronic painSemantic proximity Read ↗

Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models.Semantic proximity Read ↗

Chronic chemogenetic slow-wave-sleep enhancement in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.