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Article

Prefrontal cortex molecular clock modulates development of depression-like phenotype and rapid antidepressant response in mice.

Nature communications - 23 Aug 2024

Sarrazin David H, Gardner Wilf, Marchese Carole, Balzinger Martin, Ramanathan Chockalingam, Schott Marion, Rozov Stanislav, Veleanu Maxime, Vestring Stefan, Normann Claus, Rantamäki Tomi, Antoine Benedicte, Barrot Michel, Challet Etienne, Bourgin Patrice, Serchov Tsvetan

Abstract excerpt

Depression is associated with dysregulated circadian rhythms, but the role of intrinsic clocks in mood-controlling brain regions remains poorly understood. We found increased circadian negative loop and decreased positive clock regulators expression in the medial prefrontal cortex (mPFC) of a mouse model of depression, and a subsequent clock countermodulation by the rapid antidepressant ketamine. Selective...

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Identifiers

PMID: 39179578
DOI: 10.1038/s41467-024-51716-9
PMCID: PMC11344080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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