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Article

Mutational interference mapping experiment (MIME) for studying RNA structure and function.

Nature methods - 1 Sept 2015

Smyth Redmond P, Despons Laurence, Huili Gong, Bernacchi Serena, Hijnen Marcel, Mak Johnson, Jossinet Fabrice, Weixi Li, Paillart Jean-Christophe, von Kleist Max, Marquet Roland

Abstract excerpt

RNA regulates many biological processes; however, identifying functional RNA sequences and structures is complex and time-consuming. We introduce a method, mutational interference mapping experiment (MIME), to identify, at single-nucleotide resolution, the primary sequence and secondary structures of an RNA molecule that are crucial for its function. MIME is based on random mutagenesis of the RNA target followed...

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PMID: 26237229
DOI: 10.1038/nmeth.3490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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