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Article

Natural allelic variation of the IL-21 receptor modulates ischemic stroke infarct volume.

The Journal of clinical investigation - 1 Aug 2016

Lee Han Kyu, Keum Sehoon, Sheng Huaxin, Warner David S, Lo Donald C, Marchuk Douglas A

Abstract excerpt

Risk for ischemic stroke has a strong genetic basis, but heritable factors also contribute to the extent of damage after a stroke has occurred. We previously identified a locus on distal mouse chromosome 7 that contributes over 50% of the variation in postischemic cerebral infarct volume observed between inbred strains. Here, we used ancestral haplotype analysis to fine-map this locus to 12 candidate genes. The...

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Identifiers

PMID: 27400126
DOI: 10.1172/JCI84491
PMCID: PMC4966306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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