Article

CXCL13 Expressed on Inflamed Cerebral Blood Vessels Recruit IL-21 Producing TFH Cells to Damage Neurons Following Stroke.

2021-11-10

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Ischemic stroke is a leading cause of mortality worldwide, largely due to the inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing intensive research, there have not been any clinically approved drugs targeting the inflammatory component to stroke. Preclinical studies have identified T cells as pro-inflammatory mediators of isc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6918c5a8-a125-53f8-9261-8cd29f916868
DOI: 10.21203/rs.3.rs-1032310/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CXCL13 Expressed on Inflamed Cerebral Blood Vessels Recruit IL-21 Producing TFH Cells to Damage Neurons Following Stroke.DOI 10.21203/rs.3.rs-1032310/v1Read

FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophagesSemantic proximity Read

Induction of IRG1 following ischemic stroke promotes HO-1 and BDNF expression to alleviate neuroinflammation and restrain ischemic brain injurySemantic proximity Read

Unique Subtype of Microglia in Degenerative Thalamus After Cortical StrokeSemantic proximity Read

Innate lymphoid cells in the brain: Focus on ischemic stroke.Semantic proximity Read

Novel Therapeutic Strategy Targeting Hspa8 for Ischemic Brain InjurySemantic proximity Read

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhageSemantic proximity Read

Gut microbiota mediates trafficking of intestinal T cells to the brain to exacerbate neuroinflammation after ischemic strokeSemantic proximity Read

Early transcriptional changes in neutrophil-mediated processes following recanalization after ischemic strokeSemantic proximity Read

Therapeutically targeting neuroinflammation and microglia after acute ischemic stroke.Semantic proximity Read

Lack of cortistatin drives neuroimmune and vascular dysfunction in brain ischemiaSemantic proximity Read

Recombinant CXCL16 reduces brain injury by modulating microglial phenotype and attenuating apoptosis in acute ischemic stroke.Semantic proximity Read

Inflammation-mediated damage as a potential therapeutic target in acute ischemic stroke.Semantic proximity Read