Article
Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.
Differentiation; research in biological diversity - 1 Oct 1999
Wojcik S M, Imakado S, Seki T, Longley M A, Petherbridge L, Bundman D S, Bickenbach J R, Rothnagel J A, Roop D R
Abstract excerpt
Mouse keratin 6a (MK6a) is constitutively expressed in a single cell layer of the outer root sheath (ORS) of hair follicles, but its synthesis can be induced in interfollicular epidermis including the basal cell layer in response to perturbing stimuli. A basally inducible human K6 (HK6) isoform has not been described, and it is not clear which of the known HK6 isoforms is expressed in the ORS. In this study we...
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