Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion

8 Jul 2016

Abstract excerpt

Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-negative and HER2-negative, or "triple-negative" breast cancer (TNBC). Because phosphatases regulate the function of kinase signaling pathways, in this study, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 protein interactions
Share to Cancer-related Molecular Pathways
Share to Protein Tyrosine Phosphatases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27393618
DOI: 10.1007/s10549-016-3892-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasionPMID 27393618Read ↗

Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer.Semantic proximity Read ↗

Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype.Semantic proximity Read ↗

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancerSemantic proximity Read ↗

High ERK Protein Expression Levels Correlate with Shorter Survival in Triple-Negative Breast Cancer PatientsSemantic proximity Read ↗

Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer.Semantic proximity Read ↗

PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer CellsSemantic proximity Read ↗

Identification of dephosphorylation related genes prognostic signature in cervical squamous cell carcinoma and endocervical adenocarcinoma.Semantic proximity Read ↗

EYA4 drives breast cancer progression and metastasis through its novel role in replication stress avoidance.Semantic proximity Read ↗

LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironmentSemantic proximity Read ↗

Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathwaysSemantic proximity Read ↗

Methylation of Dual Specificity Phosphatase 4 Controls Cell DifferentiationSemantic proximity Read ↗

Functions of Shp2 in cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.