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Article

Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer.

Cancer research - 15 Oct 2013

Balko Justin M, Schwarz Luis J, Bhola Neil E, Kurupi Richard, Owens Phillip, Miller Todd W, Gómez Henry, Cook Rebecca S, Arteaga Carlos L

Abstract excerpt

Basal-like breast cancer (BLBC) is an aggressive disease that lacks a clinically approved targeted therapy. Traditional chemotherapy is effective in BLBC, but it spares the cancer stem cell (CSC)-like population, which is likely to contribute to cancer recurrence after the initial treatment. Dual...

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Identifiers

PMID: 23966295
DOI: 10.1158/0008-5472.CAN-13-1385
PMCID: PMC4090144

Genes

DUSP4
JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23966295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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