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High ERK Protein Expression Levels Correlate with Shorter Survival in Triple-Negative Breast Cancer Patients

14 May 2012

Abstract excerpt

The mitogen-activated protein kinase (MAPK) signaling pathway is known to be activated in triple-negative breast cancer (TNBC). Extracellular signal-related kinase (ERK), a member of the MAPK pathway, promotes cell proliferation, angiogenesis, cell differentiation, and cell survival. To assess the prognostic impact of ERK in TNBC patients, relative quantities of ERK (ERK-2 and pMAPK) and direct targets of the ERK...

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PMID: 22584435
DOI: 10.1634/theoncologist.2011-0377

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