Article
In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity.
Diagnostic pathology - 8 Jul 2016
Ágoston Emese Irma, Micsik Tamás, Ács Balázs, Fekete Krisztina, Hahn Oszkár, Baranyai Zsolt, Dede Kristóf, Bodoky György, Bursics Attila, Kulka Janina, Krenács Tibor, Győrffy Balázs, Harsányi László, Szász A Marcell
Abstract excerpt
BACKGROUND: Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss of function is frequently detected in advanced colorectal cancer. Its detection is thought to have prognostic significance and it is being considered to predict responsiveness to anti-EGFR therapy. Unfortunately, while immunohistochemical assessment of PTEN expression is widespread, it lacks standardization and the results are hardly...
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