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Article

Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2014

Quattrone Anna, Wozniak Agnieszka, Dewaele Barbara, Floris Giuseppe, Vanspauwen Vanessa, Van Looy Thomas, Schöffski Patrick, Rutkowski Piotr, Sciot Raf, Debiec-Rychter Maria

Abstract excerpt

Insufficiency of phosphatase and tensin homolog (PTEN) occurs in numerous tumor types and has been implicated as a resistance mechanism to receptor tyrosine kinase-targeted therapies in human cancer. In this study, we have performed a comprehensive molecular and immunohistochemical characterization of PTEN in 58 imatinib-naïve and 54 imatinib-treated gastrointestinal stromal tumors (GISTs). The findings were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24743220
DOI: 10.1038/modpathol.2014.53

Genes

PTEN
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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