Article
Discordant and heterogeneous clinically relevant genomic alterations in circulating tumor cells vs plasma DNA from men with metastatic castration resistant prostate cancer.
Genes, chromosomes & cancer - 1 Apr 2020
Gupta Santosh, Hovelson Daniel H, Kemeny Gabor, Halabi Susan, Foo Wen-Chi, Anand Monika, Somarelli Jason A, Tomlins Scott A, Antonarakis Emmanuel S, Luo Jun, Dittamore Ryan V, George Daniel J, Rothwell Colin, Nanus David M, Armstrong Andrew J, Gregory Simon G
Abstract excerpt
Circulating tumor cell (CTC) and cell-free (cf) DNA-based genomic alterations are increasingly being used for clinical decision-making in oncology. However, the concordance and discordance between paired CTC and cfDNA genomic profiles remain largely unknown. We performed comparative genomic hybridization (CGH) on CTCs and cfDNA, and low-pass whole genome sequencing (lpWGS) on cfDNA to characterize genomic...
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