Article
Micrococcin P1, a naturally occurring macrocyclic peptide inhibiting hepatitis C virus entry in a pan-genotypic manner.
Antiviral research - 1 Aug 2016
Lee Myungeun, Yang Jaewon, Park Sanghyun, Jo Eunji, Kim Hee-Young, Bae Yong-Soo, Windisch Marc P
Abstract excerpt
Hepatitis C virus (HCV) is considered a major public health concern worldwide. Despite recent advances in curing chronic hepatitis C, unmet medical needs still remain, especially due to the high economic burden of therapies. Accordingly, our study aimed to identify affordable novel HCV inhibitors by screening of natural product compound libraries. We identified micrococcin P1, a macrocyclic peptide antibiotic,...
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