Article
Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.
PloS one - 1 Jan 2014
Al Olaby Reem R, Cocquerel Laurence, Zemla Adam, Saas Laure, Dubuisson Jean, Vielmetter Jost, Marcotrigiano Joseph, Khan Abdul Ghafoor, Vences Catalan Felipe, Perryman Alexander L, Freundlich Joel S, Forli Stefano, Levy Shoshana, Balhorn Rod, Azzazy Hassan M
Abstract excerpt
Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a broader range of HCV genotypes and subtypes without being used in combination with interferon and/or ribavirin. Recently, two crystal structures of the core of the HCV...
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