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Activity-based and fraction-guided analysis of Phyllanthus urinaria identifies loliolide as a potent inhibitor of hepatitis C virus entry.

Antiviral research - 1 Jun 2016

Chung Chueh-Yao, Liu Ching-Hsuan, Burnouf Thierry, Wang Guey-Horng, Chang Shun-Pang, Jassey Alagie, Tai Chen-Jei, Tai Cheng-Jeng, Huang Ching-Jang, Richardson Christopher D, Yen Ming-Hong, Lin Chun-Ching, Lin Liang-Tzung

Abstract excerpt

Without a vaccine, hepatitis C virus (HCV) remains a global medical and socio-economic burden, predisposing about 170 million carriers worldwide to end-stage liver diseases including cirrhosis and hepatocellular carcinoma. Although the recently developed direct-acting antivirals (DAAs) have revolutionized hepatitis C treatment, most of them are unsuitable for monotherapy due to risks of resistance, thus...

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PMID: 27012176
DOI: 10.1016/j.antiviral.2016.03.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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