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Article

Novel small-molecule inhibitors of hepatitis C virus entry block viral spread and promote viral clearance in cell culture.

PloS one - 1 Jan 2012

Coburn Glen A, Fisch Danielle N, Moorji Sameer M, de Muys Jean-Marc, Murga Jose D, Paul Dorothy, Provoncha Kathleen P, Rotshteyn Yakov, Han Amy Q, Qian Dapeng, Maddon Paul J, Olson William C

Abstract excerpt

Combinations of direct-acting anti-virals offer the potential to improve the efficacy, tolerability and duration of the current treatment regimen for hepatitis C virus (HCV) infection. Viral entry represents a distinct therapeutic target that has been validated clinically for a number of pathogenic viruses. To discover novel inhibitors of HCV entry, we conducted a high throughput screen of a proprietary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22545104
DOI: 10.1371/journal.pone.0035351
PMCID: PMC3335862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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