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Article

High affinity peptide inhibitors of the hepatitis C virus NS3-4A protease refractory to common resistant mutants.

The Journal of biological chemistry - 9 Nov 2012

Kügler Jonas, Schmelz Stefan, Gentzsch Juliane, Haid Sibylle, Pollmann Erik, van den Heuvel Joop, Franke Raimo, Pietschmann Thomas, Heinz Dirk W, Collins John

Abstract excerpt

Hepatitis C virus (HCV) NS3-4A protease is essential for viral replication. All current small molecular weight drugs against NS3-4A are substrate peptidomimetics that have a similar binding and resistance profile. We developed inhibitory peptides (IPs) capping the active site and binding via a novel "tyrosine" finger at an alternative NS3-4A site that is of particular interest for further HCV drug development....

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Identifiers

PMID: 22965230
DOI: 10.1074/jbc.M112.393843
PMCID: PMC3493962

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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