MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

doi:10.1128/AAC.00324-12

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Article

MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

Antimicrobial agents and chemotherapy - 1 Aug 2012

Summa Vincenzo, Ludmerer Steven W, McCauley John A, Fandozzi Christine, Burlein Christine, Claudio Giuliano, Coleman Paul J, Dimuzio Jillian M, Ferrara Marco, Di Filippo Marcello, Gates Adam T, Graham Donald J, Harper Steven, Hazuda Daria J, Huang Qian, McHale Carolyn, Monteagudo Edith, Pucci Vincenzo, Rowley Michael, Rudd Michael T, Soriano Aileen, Stahlhut Mark W, Vacca Joseph P, Olsen David B, Liverton Nigel J, Carroll Steven S

Abstract excerpt

HCV NS3/4a protease inhibitors are proven therapeutic agents against chronic hepatitis C virus infection, with boceprevir and telaprevir having recently received regulatory approval as add-on therapy to pegylated interferon/ribavirin for patients harboring genotype 1 infections. Overcoming antiviral resistance, broad genotype coverage, and a convenient dosing regimen are important attributes for future agents to...

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PMID: 22615282
DOI: 10.1128/AAC.00324-12
PMCID: PMC3421554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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