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Article

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.

Aging - 1 Aug 2016

Kabir Tasnuva D, Leigh Ross J, Tasena Hataitip, Mellone Massimiliano, Coletta Ricardo D, Parkinson Eric K, Prime Stephen S, Thomas Gareth J, Paterson Ian C, Zhou Donghui, McCall John, Speight Paul M, Lambert Daniel W

Abstract excerpt

Senescent cancer-associated fibroblasts (CAF) develop a senescence-associated secretory phenotype (SASP) that is believed to contribute to cancer progression. The mechanisms underlying SASP development are, however, poorly understood. Here we examined the functional role of microRNA in the development of the SASP in normal fibroblasts and CAF. We identified a microRNA, miR-335, up-regulated in the senescent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27385366
DOI: 10.18632/aging.100987
PMCID: PMC5032686

Genes

PTEN
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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