Article

Targeting SERPINE1 suppresses cGAS-STING-mediated fibroblast senescence and attenuates intestinal inflammation in Crohn’s disease

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Background Cellular senescence and the senescence-associated secretory phenotype (SASP) are recognized drivers of chronic inflammation. This study aims to characterize a specific senescent fibroblast subset and its role in reshaping the immune landscape of Crohn’s disease (CD). Methods Single-cell and bulk transcriptomic data from CD patients were analyzed to identify senescent cell p...

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Literature Corpus work: 5b41d19c-cd31-5c04-aecf-a54ac2cf28d8
DOI: 10.21203/rs.3.rs-9810404/v1

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Targeting SERPINE1 suppresses cGAS-STING-mediated fibroblast senescence and attenuates intestinal inflammation in Crohn’s diseaseDOI 10.21203/rs.3.rs-9810404/v1Read

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