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Article

The first HxRxG motif in simian immunodeficiency virus mac239 Vpr is crucial for G(2)/M cell cycle arrest.

Journal of virology - 1 Nov 2002

Mueller Sandra M, Lang Sabine M

Abstract excerpt

The highly conserved Vpr protein mediates cell cycle arrest, transcriptional transactivation, and nuclear import of the preintegration complex in human immunodeficiency virus type 1. To identify functional domains in simian immunodeficiency virus (SIV) mac239 Vpr, we mutagenized selected motifs within an alpha-helical region and two C-terminal HxRxG motifs. All Vpr mutants located to the nucleus. Substitution of...

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Identifiers

PMID: 12388729
DOI: 10.1128/jvi.76.22.11704-11709.2002
PMCID: PMC136740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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