Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Virology. HIV--breaking the rules for nuclear entry.

Science (New York, N.Y.) - 2 Nov 2001

Segura-Totten M, Wilson K L

Abstract excerpt

How does human immunodeficiency virus (HIV) gain access to the carefully guarded nucleus of the host cell? In a Perspective, Segura-Totten and Wilson elaborate on new findings (de Noronha et al.) showing that the HIV protein Vpr is crucial for causing transient herniations in the host cell nuclear envelope. These ruptures are sufficient to enable the preintegration complexes of invading virions to enter the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to G2 Phase
Share to Gene Products, vpr

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lamins

Share to Nuclear Envelope

Share to Virus Integration

Share to vpr Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 11691977
DOI: 10.1126/science.1066729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Virology. HIV--breaking the rules for nuclear entry.PMID 11691977Read ↗

Let me in: Control of HIV nuclear entry at the nuclear envelopeSemantic proximity Read ↗

Nuclear Import of the Pre-Integration Complex (PIC): The Achilles Heel of HIV ?Semantic proximity Read ↗

The ins and outs of HIV replicationSemantic proximity Read ↗

HIV-1 uncoating: connection to nuclear entry and regulation by host proteinsSemantic proximity Read ↗

The Role of Capsid in HIV-1 Nuclear EntrySemantic proximity Read ↗

A Hard Way to the NucleusSemantic proximity Read ↗

Nuclear Capsid Uncoating and Reverse Transcription of HIV-1Semantic proximity Read ↗

Revisiting HIV-1 uncoatingSemantic proximity Read ↗

May I Help You with Your Coat? HIV-1 Capsid Uncoating and Reverse TranscriptionSemantic proximity Read ↗

Escape of herpesviruses from the nucleusSemantic proximity Read ↗

Capsid–host interactions for HIV-1 ingressSemantic proximity Read ↗

Remodeling of the core leads HIV-1 pre-integration complex in the nucleus of human lymphocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.