Article

NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and Tumorigenesis

2018-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Paracellular barriers play an important role in the pathogenesis of IBDs and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumor suppressor gene and inhibits colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation and colitis-associated colorectal cancer is unclear. Here, We found that intestine-specific Ndrg2 deficiency ca...

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Literature Corpus work: 6eeace53-03ca-50e7-bc62-4d37e6e08bec
DOI: 10.1101/473397

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