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Article

A developmental transcriptomic analysis of Pax1 and Pax9 in embryonic intervertebral disc development

1 Jan 2016

Abstract excerpt

Pax1 and Pax9 play redundant, synergistic functions in the patterning and differentiation of the sclerotomal cells that give rise to the vertebral bodies and intervertebral discs (IVD) of the axial skeleton. They are conserved in mice and humans, whereby mutations/deficiency of human PAX1/PAX9 have been associated with kyphoscoliosis. By combining cell-type specific transcriptome and ChIP-sequencing data, we...

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PMID: 28011632
DOI: 10.1242/bio.023218

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