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Article

Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype.

The pharmacogenomics journal - 1 Dec 2017

Vanhove T, Annaert P, Lambrechts D, Kuypers D R J

Abstract excerpt

The relevance of most genetic polymorphisms beyond CYP3A5*1 on tacrolimus disposition remains unclear. We constructed a predictive mixed model for tacrolimus dose-corrected trough concentration (C0/dose) at months 3, 12 and 24 after transplantation in a retrospective cohort of 766 predominantly Causasian adult renal recipients (n=2042 trough concentrations). All patients were genotyped for 32 single-nucleotide...

Read the complete abstract on PubMed

Topics

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Share to Tacrolimus
Share to ATP Binding Cassette Transporter, Subfamily B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Dose-Response Relationship, Drug

Share to Immunosuppressive Agents

Share to Kidney Transplantation

Share to Multidrug Resistance-Associated Protein 2

Share to Tissue Distribution

Source

Identifiers

PMID: 27378609
DOI: 10.1038/tpj.2016.49

Genes

ABCB1
ABCC2
APOA5
COMT
PPARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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