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Article

Hutchinson-Gilford progeria syndrome.

Clinical genetics - 1 Nov 2004

Pollex R L, Hegele R A

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that causes premature, rapid aging shortly after birth. Recently, de novo point mutations in the Lmna gene have been found in individuals with HGPS. Lmna encodes lamin A and C, the A-type lamins, which are an important structural component of the nuclear envelope. The most common HGPS mutation is located at codon 608 (G608G). This...

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Identifiers

PMID: 15479179
DOI: 10.1111/j.1399-0004.2004.00315.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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