Article
A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer.
Breast cancer research : BCR - 5 Jun 2014
Hollern Daniel P, Andrechek Eran R
Abstract excerpt
INTRODUCTION: Genomic variability limits the efficacy of breast cancer therapy. To simplify the study of the molecular complexity of breast cancer, researchers have used mouse mammary tumor models. However, the degree to which mouse models model human breast cancer and are reflective of the human heterogeneity has yet to be demonstrated with gene expression studies on a large scale. METHODS: To this end, we have...
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