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Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

11 Dec 2025

Abstract excerpt

Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and...

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PMID: 41381884
DOI: 10.1038/s41588-025-02419-4

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