Article
Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.
BMC cancer - 24 Aug 2010
Holstege Henne, van Beers Erik, Velds Arno, Liu Xiaoling, Joosse Simon A, Klarenbeek Sjoerd, Schut Eva, Kerkhoven Ron, Klijn Christiaan N, Wessels Lodewyk F A, Nederlof Petra M, Jonkers Jos
Abstract excerpt
BACKGROUND: Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give rise to cellular growth advantage. So far, it has not been easy to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.