Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of DNA methylation at imprinted DMRs in the spermatozoa of oligozoospermic men in association with MTHFR C677T genotype.

Andrology - 1 Sept 2016

Louie K, Minor A, Ng R, Poon K, Chow V, Ma S

Abstract excerpt

Altered DNA methylation has been previously identified in the spermatozoa of infertile men; however, the origins of these errors are poorly understood. DNA methylation is an epigenetic modification which is thought to play a fundamental role in male germline development. DNA methylation reactions rely on the cellular availability of methyl donors, which are primarily products of folate metabolism, where a key...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA Methylation
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oligospermia

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

Share to Spermatozoa

Source

Identifiers

PMID: 27369467
DOI: 10.1111/andr.12240

Genes

MTHFR
MEST

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of DNA methylation at imprinted DMRs in the spermatozoa of oligozoospermic men in association with MTHFR C677T genotype.PMID 27369467Read ↗

Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermiaSemantic proximity Read ↗

Methylation loss at<i>H19</i>imprinted gene correlates with<i><i>methylenetetrahydrofolate reductase</i></i>gene promoter hypermethylation in semen samples from infertile malesSemantic proximity Read ↗

Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men: assessment of genetic variants and assisted reproductive technology outcome.Semantic proximity Read ↗

The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.Semantic proximity Read ↗

Epigenetics of Male Infertility: The Role of DNA MethylationSemantic proximity Read ↗

The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesisSemantic proximity Read ↗

Genomic imprinting in disruptive spermatogenesis.Semantic proximity Read ↗

Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control studySemantic proximity Read ↗

High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism.Semantic proximity Read ↗

Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR).Semantic proximity Read ↗

Customized MethylC-Capture Sequencing to Evaluate Variation in the Human Sperm DNA Methylome Representative of Altered Folate MetabolismSemantic proximity Read ↗

Teratozoospermia and asthenozoospermia are associated with specific epigenetic signaturesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.