Methylation loss at<i>H19</i>imprinted gene correlates with<i><i>methylenetetrahydrofolate reductase</i></i>gene promoter hypermethylation in semen samples from infertile males

Abstract excerpt

Aberrant methylation at the H19 paternal imprinted gene has been identified in different cohorts of infertile males. The causes of H19 methylation errors are poorly understood. In this study, we investigated the methylation status of the H19 gene in semen DNA samples from infertile males affected by MTHFR gene promoter hypermethylation. DNA from normal and abnormal semen samples harbouring MTHFR gene promoter...

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