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Article

Idiopathic male infertility is strongly associated with aberrant promoter methylation of methylenetetrahydrofolate reductase (MTHFR).

PloS one - 9 Nov 2010

Wu Wei, Shen Ouxi, Qin Yufeng, Niu Xiaobing, Lu Chuncheng, Xia Yankai, Song Ling, Wang Shoulin, Wang Xinru

Abstract excerpt

BACKGROUND: Abnormal germline DNA methylation in males has been proposed as a possible mechanism compromising spermatogenesis of some men currently diagnosed with idiopathic infertility. Previous studies have been focused on imprinted genes with DNA methylation in poor quality human sperms. However, recent but limited data have revealed that sperm methylation abnormalities may involve large numbers of genes or...

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Share to DNA Methylation
Share to Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Logistic Models

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Oligospermia

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 21085488
DOI: 10.1371/journal.pone.0013884
PMCID: PMC2976703

Genes

MTHFR

Provenance

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