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Article

The sperm epigenome does not display recurrent epimutations in patients with severely impaired spermatogenesis.

Clinical epigenetics - 6 May 2020

Leitão Elsa, Di Persio Sara, Laurentino Sandra, Wöste Marius, Dugas Martin, Kliesch Sabine, Neuhaus Nina, Horsthemke Bernhard

Abstract excerpt

BACKGROUND: In the past 15 years, numerous studies have described aberrant DNA methylation of imprinted genes (e.g. MEST and H19) in sperm of oligozoospermic men, but the prevalence and genomic extent of abnormal methylation patterns have remained unknown. RESULTS: Using deep bisulfite sequencing (DBS), we screened swim-up sperm samples from 40 normozoospermic and 93 patients diagnosed as...

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Share to Azoospermia
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Genomic Imprinting

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Share to RNA, Long Noncoding

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Share to Whole Genome Sequencing

Source

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Identifiers

PMID: 32375885
DOI: 10.1186/s13148-020-00854-0
PMCID: PMC7204326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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