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Article

Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice.

Biological psychiatry - 1 Mar 2006

Gemelli Terry, Berton Olivier, Nelson Erika D, Perrotti Linda I, Jaenisch Rudolf, Monteggia Lisa M

Abstract excerpt

BACKGROUND: Mutations in the methyl-CpG binding protein 2 (MeCP2) gene cause Rett syndrome (RTT), a neurodevelopmental disorder that is accompanied by a broad array of behavioral phenotypes, mainly affecting females. Methyl-CpG binding protein 2 is a transcriptional repressor that is widely expre...

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Source

Identifiers

PMID: 16199017
DOI: 10.1016/j.biopsych.2005.07.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16199017-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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