Article
Whole exome sequencing in families at high risk for Hodgkin lymphoma: identification of a predisposing mutation in the KDR gene.
Haematologica - 1 Jul 2016
Rotunno Melissa, McMaster Mary L, Boland Joseph, Bass Sara, Zhang Xijun, Burdett Laurie, Hicks Belynda, Ravichandran Sarangan, Luke Brian T, Yeager Meredith, Fontaine Laura, Hyland Paula L, Goldstein Alisa M, Chanock Stephen J, Caporaso Neil E, Tucker Margaret A, Goldin Lynn R
Abstract excerpt
Hodgkin lymphoma shows strong familial aggregation but no major susceptibility genes have been identified to date. The goal of this study was to identify high-penetrance variants using whole exome sequencing in 17 Hodgkin lymphoma prone families with three or more affected cases or obligate carriers (69 individuals), followed by targeted sequencing in an additional 48 smaller HL families (80 individuals)....
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