Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.

doi:10.1158/2767-9764.CRC-23-0140

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Article

Ultra-Deep Sequencing Reveals the Mutational Landscape of Classical Hodgkin Lymphoma.

Cancer research communications - 15 Nov 2023

Gomez Felicia, Fisk Bryan, McMichael Joshua F, Mosior Matthew, Foltz Jennifer A, Skidmore Zachary L, Duncavage Eric J, Miller Christopher A, Abel Haley, Li Yi-Shan, Russler-Germain David A, Krysiak Kilannin, Watkins Marcus P, Ramirez Cody A, Schmidt Alina, Martins Rodrigues Fernanda, Trani Lee, Khanna Ajay, Wagner Julia A, Fulton Robert S, Fronick Catrina C, O'Laughlin Michelle D, Schappe Timothy, Cashen Amanda F, Mehta-Shah Neha, Kahl Brad S, Walker Jason, Bartlett Nancy L, Griffith Malachi, Fehniger Todd A, Griffith Obi L

Abstract excerpt

The malignant Hodgkin and Reed Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) are scarce in affected lymph nodes, creating a challenge to detect driver somatic mutations. As an alternative to cell purification techniques, we hypothesized that ultra-deep exome sequencing would allow genomic study of HRS cells, thereby streamlining analysis and avoiding technical pitfalls. To test this, 31 cHL...

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Identifiers

PMID: 37910143
DOI: 10.1158/2767-9764.CRC-23-0140
PMCID: PMC10648575

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