Article
Association of single nucleotide variants in VEGFA and KDR with the risk and angiogenic features of diffuse large B-cell lymphoma.
Leukemia & lymphoma - 1 Dec 2023
Assis-Mendonça Guilherme Rossi, Campos Letícia Goulart, Delamain Márcia Torresan, de Brito Angelo Borsarelli Carvalho, Fanelli Marcello Ferreti, Soares Fernando Augusto, de Souza Cármino Antônio, Vassallo José, Lima Carmen Silvia Passos
Abstract excerpt
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma subtype and dependent on angiogenesis (AG), whose main effectors are VEGFA and VEGFR2. Functional single nucleotide variants (SNVs) are described in VEGFA and KDR genes. However, it still unknown whether VEGFA - 2578C/A, -2489C/T, -1154G/A, -634G/C, -460C/T and KDR-604T/C, -271G/A, +1192G/A and +1719A/T SNVs act on DLBCL risk and angiogenic...
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