Article
Discovery of novel predisposing coding and noncoding variants in familial Hodgkin lymphoma.
Blood - 16 Mar 2023
Flerlage Jamie E, Myers Jason R, Maciaszek Jamie L, Oak Ninad, Rashkin Sara R, Hui Yawei, Wang Yong-Dong, Chen Wenan, Wu Gang, Chang Ti-Cheng, Hamilton Kayla, Tithi Saima S, Goldin Lynn R, Rotunno Melissa, Caporaso Neil, Vogt Aurélie, Flamish Deborah, Wyatt Kathleen, Liu Jia, Tucker Margaret, Hahn Christopher N, Brown Anna L, Scott Hamish S, Mullighan Charles, Nichols Kim E, Metzger Monika L, McMaster Mary L, Yang Jun J, Rampersaud Evadnie
Abstract excerpt
Familial aggregation of Hodgkin lymphoma (HL) has been demonstrated in large population studies, pointing to genetic predisposition to this hematological malignancy. To understand the genetic variants associated with the development of HL, we performed whole genome sequencing on 234 individuals with and without HL from 36 pedigrees that had 2 or more first-degree relatives with HL. Our pedigree selection criteria...
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