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Article

Liquid biopsy: a non-invasive approach for Hodgkin lymphoma genotyping.

British journal of haematology - 1 Nov 2021

Alcoceba Miguel, García-Álvarez María, Chillón M Carmen, Jiménez Cristina, Medina Alejandro, Antón Alicia, Blanco Oscar, Díaz Luis G, Tamayo Pilar, González-Calle Verónica, Vidal María Jesús, Cuello Rebeca, Díaz Gálvez Francisco Javier, Queizán José Antonio, Martín Alejandro, González Marcos, García-Sanz Ramón, Sarasquete M Eugenia

Abstract excerpt

The Hodgkin lymphoma (HL) genomic landscape is hardly known due to the scarcity of tumour cells in the tissue. Liquid biopsy employing circulating tumour DNA (ctDNA) can emerge as an alternative tool for non-invasive genotyping. By using a custom next generation sequencing (NGS) panel in combination with unique molecule identifiers, we aimed to identify somatic variants in the ctDNA of 60 HL at diagnosis. A total...

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PMID: 34312841
DOI: 10.1111/bjh.17719

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