Article
Exome sequencing reveals germline NPAT mutation as a candidate risk factor for Hodgkin lymphoma.
Blood - 21 Jul 2011
Saarinen Silva, Aavikko Mervi, Aittomäki Kristiina, Launonen Virpi, Lehtonen Rainer, Franssila Kaarle, Lehtonen Heli J, Kaasinen Eevi, Broderick Peter, Tarkkanen Jussi, Bain Barbara J, Bauduer Frédéric, Ünal Ali, Swerdlow Anthony J, Cooke Rosie, Mäkinen Markus J, Houlston Richard, Vahteristo Pia, Aaltonen Lauri A
Abstract excerpt
A strong clustering of Hodgkin lymphoma in certain families has been long acknowledged. However, the genetic factors in the background of familial Hodgkin lymphoma are largely unknown. We have studied a family of 4 cousins with a rare subtype of the disease, nodular lymphocyte predominant Hodgkin lymphoma. We applied exome sequencing together with genome-wide linkage analysis to this family and identified a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.