Article
Association of Polymorphisms in Connective Tissue Growth Factor and Epidermal Growth Factor Receptor Genes With Human Longevity.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Aug 2017
Donlon Timothy A, Morris Brian J, He Qimei, Chen Randi, Masaki Kamal H, Allsopp Richard C, Willcox D Craig, Tranah Gregory J, Parimi Neeta, Evans Daniel S, Flachsbart Friederike, Nebel Almut, Kim Duk-Hwan, Park Joobae, Willcox Bradley J
Abstract excerpt
Growth pathways play key roles in longevity. The present study tested single-nucleotide polymorphisms (SNPs) in the connective tissue growth factor gene (CTGF) and the epidermal growth factor receptor gene (EGFR) for association with longevity. Comparison of allele and genotype frequencies of 12 CTGF SNPs and 41 EGFR SNPs between 440 American men of Japanese ancestry aged ≥95 years and 374 men of average life...
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