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Article

Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis.

Developmental biology - 1 Nov 2010

He Fenglei, Xiong Wei, Wang Ying, Matsui Maiko, Yu Xueyan, Chai Yang, Klingensmith John, Chen Yiping

Abstract excerpt

BMP signaling plays many important roles during organ development, including palatogenesis. Loss of BMP signaling leads to cleft palate formation. During development, BMP activities are finely tuned by a number of modulators at the extracellular and intracellular levels. Among the extracellular BMP antagonists is Noggin, which preferentialy binds to BMP2, BMP4 and BMP7, all of which are expressed in the...

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Source

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Identifiers

PMID: 20727875
DOI: 10.1016/j.ydbio.2010.08.014
PMCID: PMC3010875

Genes

BMP2
BMP4
BMP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis.PMID 20727875Read ↗

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Biological Mechanisms in Palatogenesis and Cleft PalateSemantic proximity Read ↗

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Noggin is required for first pharyngeal arch differentiation in the frog Xenopus tropicalis.Semantic proximity Read ↗

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