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Article

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.

Aging cell - 1 Oct 2016

Lee Benjamin P, Pilling Luke C, Emond Florence, Flurkey Kevin, Harrison David E, Yuan Rong, Peters Luanne L, Kuchel George A, Ferrucci Luigi, Melzer David, Harries Lorna W

Abstract excerpt

Dysregulation of splicing factor expression and altered alternative splicing are associated with aging in humans and other species, and also with replicative senescence in cultured cells. Here, we assess whether expression changes of key splicing regulator genes and consequent effects on alternative splicing are also associated with strain longevity in old and young mice, across 6 different mouse strains with...

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Source

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Identifiers

PMID: 27363602
DOI: 10.1111/acel.12499
PMCID: PMC5013025

Genes

HNRNPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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