Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.

GeroScience - 1 Apr 2020

Lee B P, Smith M, Buffenstein R, Harries L W

Abstract excerpt

Naked mole-rats (NMRs) have amongst the longest lifespans relative to body size of any known, non-volant mammalian species. They also display an enhanced stress resistance phenotype, negligible senescence and very rarely are they burdened with chronic age-related diseases. Alternative splicing (AS) dysregulation is emerging as a potential driver of senescence and ageing. We hypothesised that the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Brain
Share to Longevity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to RNA Research and Splicing

Share to RNA Splicing Factors

Share to Telomeres, Telomerase, and Senescence

Source

Open in PubMed Open full text

Identifiers

PMID: 31927681
DOI: 10.1007/s11357-019-00150-7
PMCID: PMC7205774

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negligible senescence in naked mole rats may be a consequence of well-maintained splicing regulation.PMID 31927681Read ↗

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.Semantic proximity Read ↗

The landscape of the alternatively spliced transcriptome remains stable during aging across different species and tissuesSemantic proximity Read ↗

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read ↗

The Naked Mole-Rat: A New Long-Living Model for Human Aging ResearchSemantic proximity Read ↗

Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescenceSemantic proximity Read ↗

Comparative study of protein aggregation propensity and mutation tolerance between naked mole-rat and mouseSemantic proximity Read ↗

Pre-mRNA splicing modulations in senescence.Semantic proximity Read ↗

Alternative splicing in aging and longevity.Semantic proximity Read ↗

Comparative Study of Protein Aggregation Propensity and Mutation Tolerance Between Naked Mole-Rat and Mouse.Semantic proximity Read ↗

The emerging role of alternative splicing in senescence and agingSemantic proximity Read ↗

Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevitySemantic proximity Read ↗

Aging is associated with a systemic length-driven transcriptome imbalanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.