Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer Growth

29 Jun 2016

Abstract excerpt

Stat5a is a transcription factor utilized by several cytokine/hormone receptor signaling pathways that promotes transcription of genes associated with proliferation, differentiation, and survival of cancer cells. However, there are currently no clinically approved therapies that directly target Stat5a, despite ample evidence that it contributes to breast cancer pathogenesis. Here, deacetylation of the Stat5a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Histone Deacetylase Inhibitors Research
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27358110
DOI: 10.1158/1541-7786.mcr-16-0109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HDAC6 Deacetylates HMGN2 to Regulate Stat5a Activity and Breast Cancer GrowthPMID 27358110Read ↗

HMGN5 escorts oncogenic STAT3 signaling by regulating chromatin landscape in tumorigenesis of breast cancerSemantic proximity Read ↗

Histone deacetylase 6 in cancerSemantic proximity Read ↗

STAT5 acetylationSemantic proximity Read ↗

High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote TumorigenesisSemantic proximity Read ↗

Role of HMGB1 and its associated signaling pathways in human malignanciesSemantic proximity Read ↗

HDAC6: Tumor Progression and BeyondSemantic proximity Read ↗

Elevated HMGA2 expression is associated with cancer aggressiveness and predicts poor outcome in breast cancer.Semantic proximity Read ↗

RGS6 inhibits the proliferation, migration, and invasion of breast cancer through the SMAD6-HMGA1 signaling pathwaySemantic proximity Read ↗

HMGN2 inducibly binds a novel transactivation domain in nuclear PRLr to coordinate Stat5a-mediated transcription.Semantic proximity Read ↗

Leukemia Risk Factor ARID5B Coordinates HDAC-Mediated Transcriptional RepressionSemantic proximity Read ↗

HDAC6 and Ovarian CancerSemantic proximity Read ↗

HMGA 2 promotes glioma invasion and poor prognosis via a long‐range chromatin interactionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.