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Article

A loss of function variant in CASP7 protects against Alzheimer's disease in homozygous APOE ε4 allele carriers.

BMC genomics - 23 Jun 2016

Ayers Kristin L, Mirshahi Uyenlinh L, Wardeh Amr H, Murray Michael F, Hao Ke, Glicksberg Benjamin S, Li Shuyu, Carey David J, Chen Rong

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) represents the most common form of dementia in elder populations with approximately 30 million cases worldwide. Genome wide genotyping and sequencing studies have identified many genetic variants associated with late-onset Alzheimer's disease (LOAD). While most of these variants are associated with increased risk of developing LOAD, only limited number of reports focused on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27358062
DOI: 10.1186/s12864-016-2725-z
PMCID: PMC4928152

Genes

APOE
CASP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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