Article
Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study.
The Lancet. Neurology - 1 Aug 2015
Cuyvers Elise, De Roeck Arne, Van den Bossche Tobi, Van Cauwenberghe Caroline, Bettens Karolien, Vermeulen Steven, Mattheijssens Maria, Peeters Karin, Engelborghs Sebastiaan, Vandenbulcke Mathieu, Vandenberghe Rik, De Deyn Peter P, Van Broeckhoven Christine, Sleegers Kristel
Abstract excerpt
BACKGROUND: ABCA7 was identified as a risk gene for Alzheimer's disease in genome-wide association studies (GWAS). It was one of the genes most strongly associated with risk of Alzheimer's disease in a Belgian cohort. Using targeted resequencing, we investigated ABCA7 in this cohort with the aim to directly detect rare and common variations in this gene associated with Alzheimer's disease pathogenesis. METHODS:...
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