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Article

A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Mar 2019

Zhang Xiaoling, Zhu Congcong, Beecham Gary, Vardarajan Badri N, Ma Yiyi, Lancour Daniel, Farrell John J, Chung Jaeyoon, Mayeux Richard, Haines Jonathan L, Schellenberg Gerard D, Pericak-Vance Margaret A, Lunetta Kathryn L, Farrer Lindsay A

Abstract excerpt

INTRODUCTION: The genetic architecture of Alzheimer's disease (AD) is only partially understood. METHODS: We conducted an association study for AD using whole sequence data from 507 genetically enriched AD cases (i.e., cases having close relatives affected by AD) and 4917 cognitively healthy controls of European ancestry (EA) and 172 enriched cases and 179 controls of Caribbean Hispanic ancestry. Confirmation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30503768
DOI: 10.1016/j.jalz.2018.10.005
PMCID: PMC6408965

Genes

CASP7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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