Article
FADD is a key regulator of lipid metabolism.
EMBO molecular medicine - 1 Aug 2016
Zhuang Hongqin, Wang Xueshi, Zha Daolong, Gan Ziyi, Cai Fangfang, Du Pan, Yang Yunwen, Yang Bingya, Zhang Xiangyu, Yao Chun, Zhou Yuqiang, Jiang Chizhou, Guan Shengwen, Zhang Xuerui, Zhang Jing, Jiang Wenhui, Hu Qingang, Hua Zi-Chun
Abstract excerpt
FADD, a classical apoptotic signaling adaptor, was recently reported to have non-apoptotic functions. Here, we report the discovery that FADD regulates lipid metabolism. PPAR-α is a dietary lipid sensor, whose activation results in hypolipidemic effects. We show that FADD interacts with RIP140, which is a corepressor for PPAR-α, and FADD phosphorylation-mimic mutation (FADD-D) or FADD deficiency abolishes...
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