Article
Nuclear receptor corepressor RIP140 regulates fat accumulation.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 2004
Leonardsson Göran, Steel Jenny H, Christian Mark, Pocock Victoria, Milligan Stuart, Bell Jimmy, So Po-Wah, Medina-Gomez Gema, Vidal-Puig Antonio, White Roger, Parker Malcolm G
Abstract excerpt
Nuclear receptors and their coactivators have been shown to function as key regulators of adipose tissue biology. Here we show that a ligand-dependent transcriptional repressor for nuclear receptors plays a crucial role in regulating the balance between energy storage and energy expenditure. Mice devoid of the corepressor protein RIP140 are lean, show resistance to high-fat diet-induced obesity and hepatic...
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